Pro-inflammatory transcription factors are proteins that regulate the expression of genes involved in the inflammatory response. Key players include NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), AP-1 (activator protein 1), and various STATs (signal transducer and activator of transcription proteins). These transcription factors are activated in response to stimuli like cytokines, pathogens, and oxidative stress, triggering the production of pro-inflammatory cytokines and chemokines. In human trials, although primarily focused on its effects on erectile dysfunction, some studies have observed reductions in markers of systemic inflammation in patients treated with Sildigra 250. These findings suggest a potential broader impact of Sildigra 250 Mg on inflammatory pathways beyond its immediate therapeutic target.